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Clinical evidence

As a pioneer in the field of liver related elastography, FibroScan® is recognized worldwide as the non-invasive gold standard solution for liver fibrosis and liver steatosis assessment with more than 2,500 peer reviewed publications.

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Unique biomarkers for fibrosis and steatosis assessment

Our one-of-a-kind parameters

LSM by VCTE (Liver Stiffness Measurement by Vibration-Controlled Transient Elastography), CAP™ (controlled attenuation parameter) and SSM by VCTE™ (Spleen Stiffness Measurement) enable point of care, non-invasive diagnosis and monitoring.

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LSM by VCTE™ for liver fibrosis assessment

LSM by VCTE™ is unique, patented and validated for liver fibrosis assessment. It is the standard for non-invasive evaluation of liver stiffness.1

2,250 peer-reviewed publications support the use of LSM by VCTE™.

CAP™ for liver steatosis assessment

CAP™ is unique, patented and validated for liver steatosis assessment.2,3

330 international and peer-reviewed articles support the use of CAP™.

SSM by VCTE™ for portal hypertension assessment

SSM by VCTE™ is unique, patented and validated for portal hypertension assessment and can be used for risk stratification of patients with advanced chronic liver disease.4

100 peer-reviewed publications support the use of SSM by VCTE™.

The new standard parameters for a better diagnosis and monitoring of chronic liver disease

2,500 peer-reviewed publications and more than 70 international guidelines evaluating, reporting or citing LSM by VCTE and CAP™.

fibroscan publications

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VCTE™ can be used to accurately diagnose cirrhosis at an acceptable rate of false negatives and false positives in patients with chronic liver disease.

AASLD | Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328-357.doi:10.1002/hep.29367

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CAP™ is a point-of-care, standardized and reproducible technique, promising for the detection of liver steatosis.

WFUMB | Ferraioli G, Wong VW-S, Castera L, et al. Liver Ultrasound Elastography: An Update to the World Federation for Ultrasound in Medicine and Biology Guidelines and Recommendations. Ultrasound Med Biol. 2018;44(12):2419-2440. doi:10.1016/j.ultrasmedbio.2018.07.008

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TE is an established technique and is recommended as the initial assessment for significant liver fibrosis and cirrhosis (A1).

TE is a highly reproducible and user-friendly technique for assessing liver fibrosis in patients with chronic liver disease.

APASL | Shiha G, Ibrahim A, Helmy A, et al. Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update. Hepatol Int. 2017;11(1):1-30. doi:10.1007/s12072-016-9760-3

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TE can be considered the non-invasive standard for the measurement of liver stiffness.

TE: Most widely used and validated technique for measurement of liver stiffness: standard to be beaten.

EASL | European Association for Study of Liver, Asociacion Latinoamericana para el Estudio del Higado. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol. 2015;63(1):237-264. doi:10.1016/j.jhep.2015.04.006

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Vibration-controlled transient elastography (VCTE) is the most commonly used imaging-based fibrosis assessment method in the United States.

It has been validated in large cohorts worldwide in a spectrum of liver diseases, including hepatitis B, hepatitis C, fatty liver disease and autoimmune liver disorders, among others.

AGA | Lim JK, Flamm SL, Singh S, Falck-Ytter YT; Clinical Guidelines Committee of the American Gastroenterological Association. American Gastroenterological Association Institute Guideline on the Role of Elastography in the Evaluation of Liver Fibrosis. Gastroenterology. 2017 May;152(6):1536-1543. doi: 10.1053/j.gastro.2017.03.017. PMID: 28442119.

References are available in our bibliography.